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STARD6 on steroids: solution structure, multiple timescale backbone dynamics and ligand binding mechanism

START domain proteins are conserved α/β helix-grip fold that play a role in the non-vesicular and intracellular transport of lipids and sterols. The mechanism and conformational changes permitting the entry of the ligand into their buried binding sites is not well understood. Moreover, their functio...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Létourneau, Danny, Bédard, Mikaël, Cabana, Jérôme, Lefebvre, Andrée, LeHoux, Jean-Guy, Lavigne, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919784/
https://ncbi.nlm.nih.gov/pubmed/27340016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28486
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