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Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore
[Image: see text] We describe a general method to synthesize the iminium tetrahydrothiophene embedded in the dimeric Nuphar alkaloids. In contrast to prior studies, the sulfur atom of the thiaspirane pharmacophore is shown to be electrophilic. This α-thioether reacts with thiophenol or glutathione a...
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| Publicado no: | ACS Cent Sci |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2016
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4919772/ https://ncbi.nlm.nih.gov/pubmed/27413784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.6b00113 |
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