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Myeloid-Specific Blockade of Notch Signaling Attenuates Choroidal Neovascularization through Compromised Macrophage Infiltration and Polarization in Mice

Macrophages have been recognized as an important inflammatory component in choroidal neovascularization (CNV). However, it is unclear how these cells are activated and polarized, how they affect angiogenesis and what the underlining mechanisms are during CNV. Notch signaling has been implicated in m...

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Detalhes bibliográficos
Publicado no:Sci Rep
Principais autores: Dou, Guo-Rui, Li, Na, Chang, Tian-Fang, Zhang, Ping, Gao, Xiang, Yan, Xian-Chun, Liang, Liang, Han, Hua, Wang, Yu-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919651/
https://ncbi.nlm.nih.gov/pubmed/27339903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28617
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