Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production

Fanconi Anemia (FA) is a genetic disorder characterized by elevated cancer susceptibility and pro-inflammatory cytokine production. Using SLX4(FANCP) deficiency as a working model, we questioned the trigger for chronic inflammation in FA. We found that absence of SLX4 caused cytoplasmic DNA accumula...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Brégnard, Christelle, Guerra, Jessica, Déjardin, Stéphanie, Passalacqua, Frank, Benkirane, Monsef, Laguette, Nadine
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919473/
https://ncbi.nlm.nih.gov/pubmed/27428429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.05.005
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