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cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

The antiinflammatory glucocorticoids are potent inhibitors of cyclooxygenase, a key regulator of prostaglandin synthesis; yet, the mechanism(s) by which this occurs is not fully understood. We have cloned a 4.1-kilobase (kb) cDNA, distinct from the previously cloned cyclooxygenase (2.8 kb), that con...

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Autors principals: O'Banion, M K, Winn, V D, Young, D A
Format: Artigo
Idioma:Inglês
Publicat: 1992
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC49193/
https://ncbi.nlm.nih.gov/pubmed/1594589
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