The adenoviral E1A N-terminal domain represses MYC transcription in human cancer cells by targeting both p300 and TRRAP and inhibiting MYC promoter acetylation of H3K18 and H4K16

Human cancers frequently arise from increased expression of proto-oncogenes, such as MYC and HER2. Understanding the cellular pathways regulating the transcription and expression of proto-oncogenes is important for targeted therapies for cancer treatment. Adenoviral (Ad) E1A 243R (243 aa residues) i...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Genes Cancer
Hlavní autoři: Zhao, Ling-Jun, Loewenstein, Paul M., Green, Maurice
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918948/
https://ncbi.nlm.nih.gov/pubmed/27382434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/genesandcancer.99
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky