Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies

In response to stimuli, biological processes are tightly controlled by dynamic cellular signaling mechanisms. Reversible protein phosphorylation occurs on rapid time-scales (milliseconds to seconds), making it an ideal carrier of these signals. Advances in mass spectrometry-based proteomics have led...

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Publicado en:PLoS One
Autores principales: Domanova, Westa, Krycer, James, Chaudhuri, Rima, Yang, Pengyi, Vafaee, Fatemeh, Fazakerley, Daniel, Humphrey, Sean, James, David, Kuncic, Zdenka
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918924/
https://ncbi.nlm.nih.gov/pubmed/27336693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157763
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