Determination by systematic deletion of the amino acids essential for catalysis by ricin A chain.
The A chain of ricin is a RNA N-glycosidase that inactivates ribosomes by depurination of a single adenosine in 28S rRNA. Of the 267 amino acids in the protein, 222 (83%) could be deleted from one or another of 74 mutants without loss of the capacity of the protein to recognize a single nucleotide f...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1594586/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.11.4869 |
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