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Pharmacokinetic and Tumor Distribution Characteristics of Temsirolimus in Patients with Recurrent Malignant Glioma

PURPOSE: To characterize the pharmacokinetics of temsirolimus and its major metabolite, sirolimus, in patients receiving enzyme-inducing antiepileptic drugs (EIAED) compared with patients receiving non-EIAEDs. An additional objective was to determine whether concentrations of temsirolimus or sirolim...

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Detaylı Bibliyografya
Yayımlandı:Clin Cancer Res
Asıl Yazarlar: Kuhn, John G., Chang, Susan M., Wen, Patrick Y., Cloughesy, Timothy F., Greenberg, Harry, Schiff, David, Conrad, Charles, Fink, Karen L., Robins, H. Ian, Mehta, Minesh, DeAngelis, Lisa, Raizer, Jeffrey, Hess, Kenneth, Lamborn, Kathleen R., Dancey, Janet, Prados, Michael D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918812/
https://ncbi.nlm.nih.gov/pubmed/18094423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-0781
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