Pharmacokinetic and Tumor Distribution Characteristics of Temsirolimus in Patients with Recurrent Malignant Glioma

PURPOSE: To characterize the pharmacokinetics of temsirolimus and its major metabolite, sirolimus, in patients receiving enzyme-inducing antiepileptic drugs (EIAED) compared with patients receiving non-EIAEDs. An additional objective was to determine whether concentrations of temsirolimus or sirolim...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Kuhn, John G., Chang, Susan M., Wen, Patrick Y., Cloughesy, Timothy F., Greenberg, Harry, Schiff, David, Conrad, Charles, Fink, Karen L., Robins, H. Ian, Mehta, Minesh, DeAngelis, Lisa, Raizer, Jeffrey, Hess, Kenneth, Lamborn, Kathleen R., Dancey, Janet, Prados, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918812/
https://ncbi.nlm.nih.gov/pubmed/18094423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-0781
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