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Mechanism of extracellular ion exchange and binding-site occlusion in the sodium-calcium exchanger
Na(+)/Ca(2+) exchangers utilize the Na(+) electrochemical gradient across the plasma membrane to extrude intracellular Ca(2+), and play a central role in Ca(2+) homeostasis. Here, we elucidate their mechanisms of extracellular ion recognition and exchange through a structural analysis of the exchang...
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| Publié dans: | Nat Struct Mol Biol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4918766/ https://ncbi.nlm.nih.gov/pubmed/27183196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3230 |
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