Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy

Unsustained enzyme inhibition is a barrier to targeted therapy for cancer. Here, resistance to a class I PI3K inhibitor in a model of metastatic breast cancer driven by PI3K and MYC was associated with feedback activation of tyrosine kinase receptors (RTKs), AKT, mTOR, and MYC. Inhibitors of bromodo...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Stratikopoulos, Elias E., Dendy, Meaghan, Szabolcs, Matthias, Khaykin, Alan J., Lefebvre, Celine, Zhou, Ming-Ming, Parsons, Ramon
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918409/
https://ncbi.nlm.nih.gov/pubmed/26058079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.05.006
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