Development of a population pharmacokinetic–pharmacodynamic model of a single bolus dose of unfractionated heparin in paediatric patients

BACKGROUND: Unfractionated heparin (UFH) is the anticoagulant of choice in paediatric patients undergoing a variety of cardiac procedures. There are currently no population pharmacokinetic–pharmacodynamic (PKPD) models for UFH in paediatrics. OBJECTIVE: The aim of the present study was to develop an...

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Bibliografiske detaljer
Udgivet i:Br J Clin Pharmacol
Main Authors: Al‐Sallami, Hesham, Newall, Fiona, Monagle, Paul, Ignjatovic, Vera, Cranswick, Noel, Duffull, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Paediatric Clinical Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917811/
https://ncbi.nlm.nih.gov/pubmed/26972703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12930
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