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ppGpp Couples Transcription to DNA Repair in E. coli
The small molecule alarmone (p)ppGpp mediates bacterial adaptation to nutrient deprivation by altering the initiation properties of RNA polymerase (RNAP). ppGpp is generated in E. coli by two related enzymes, RelA and SpoT. We show that ppGpp is robustly, but transiently, induced in response to DNA...
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| Udgivet i: | Science |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4917784/ https://ncbi.nlm.nih.gov/pubmed/27199428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad6945 |
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