Colon Cancer Cells Gene Expression Signature As Response to 5- Fluorouracil, Oxaliplatin, and Folinic Acid Treatment

5-FU cytotoxicity mechanism has been assigned both to the miss-incorporation of fluoronucleotides into RNA and DNA and to the inhibition of thymidylate synthase. 5-FU is one of the most widely used chemotherapeutic drugs, although it has severe side effects that may vary between patients. Pharmacoge...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Negrei, Carolina, Hudita, Ariana, Ginghina, Octav, Galateanu, Bianca, Voicu, Sorina Nicoleta, Stan, Miriana, Costache, Marieta, Fenga, Concettina, Drakoulis, Nikolaos, Tsatsakis, Aristidis M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917556/
https://ncbi.nlm.nih.gov/pubmed/27445811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00172
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