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Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state

OBJECTIVE: Pain resulting from local tissue injury or inflammation typically resolves with time. Frequently, however, this pain may unexpectedly persist, becoming a pathological chronic state. Increasingly, the innate and adaptive immune systems are being implicated in the initiation and maintenance...

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Dettagli Bibliografici
Pubblicato in:Brain Behav Immun
Autori principali: Woller, Sarah A., Ravula, Satheesh B., Tucci, Fabio C., Beaton, Graham, Corr, Maripat, Isseroff, R. Rivkah, Soulika, Athena M., Chigbrow, Marianne, Eddinger, Kelly A., Yaksh, Tony L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917460/
https://ncbi.nlm.nih.gov/pubmed/27044335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2016.03.026
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