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DRUG EVALUATION: Pharmacodynamic assessment of vedolizumab for the treatment of ulcerative colitis
INTRODUCTION: Vedolizumab is an anti-integrin approved for the treatment of Crohn’s disease and ulcerative colitis. By binding the α4β7-integrin heterodimer, vedolizumab blocks leukocyte translocation into gastrointestinal tissue. AREAS COVERED: This review discusses the chemistry, pharmacologic pro...
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| Udgivet i: | Expert Opin Drug Metab Toxicol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4917449/ https://ncbi.nlm.nih.gov/pubmed/27096357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/17425255.2016.1181171 |
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