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Using Clinical Trial Simulators to Analyse the Sources of Variance in Clinical Trials of Novel Therapies for Acute Viral Infections

BACKGROUND: About 90% of drugs fail in clinical development. The question is whether trials fail because of insufficient efficacy of the new treatment, or rather because of poor trial design that is unable to detect the true efficacy. The variance of the measured endpoints is a major, largely undere...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Vegvari, Carolin, Cauët, Emilie, Hadjichrysanthou, Christoforos, Lawrence, Emma, Weverling, Gerrit-Jan, de Wolf, Frank, Anderson, Roy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917234/
https://ncbi.nlm.nih.gov/pubmed/27332704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156622
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