Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice

Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair enzyme NEIL3 was associated with increased risk of myocardial infarction. Here, we explored the role of Neil3/NEIL3 in atherogenesis by both clini...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Skarpengland, Tonje, Holm, Sverre, Scheffler, Katja, Gregersen, Ida, Dahl, Tuva B., Suganthan, Rajikala, Segers, Filip M., Østlie, Ingunn, Otten, Jeroen J. T., Luna, Luisa, Ketelhuth, Daniel F. J., Lundberg, Anna M., Neurauter, Christine G., Hildrestrand, Gunn, Skjelland, Mona, Bjørndal, Bodil, Svardal, Asbjørn M., Iversen, Per O., Hedin, Ulf, Nygård, Ståle, Olstad, Ole K., Krohg-Sørensen, Kirsten, Slupphaug, Geir, Eide, Lars, Kuśnierczyk, Anna, Folkersen, Lasse, Ueland, Thor, Berge, Rolf K., Hansson, Göran K., Biessen, Erik A. L., Halvorsen, Bente, Bjørås, Magnar, Aukrust, Pål
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916448/
https://ncbi.nlm.nih.gov/pubmed/27328939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28337
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