Intrinsic hepatocyte dedifferentiation is accompanied by upregulation of mesenchymal markers, protein sialylation and core alpha 1,6 linked fucosylation

Alterations in N-linked glycosylation have long been associated with cancer but for the most part, the reasons why have remained poorly understood. Here we show that increased core fucosylation is associated with de-differentiation of primary hepatocytes and with the appearance of markers indicative...

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Udgivet i:Sci Rep
Main Authors: Mehta, Anand, Comunale, Mary Ann, Rawat, Siddhartha, Casciano, Jessica C., Lamontagne, Jason, Herrera, Harmin, Ramanathan, Aarti, Betesh, Lucy, Wang, Mengjun, Norton, Pamela, Steel, Laura F., Bouchard, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916422/
https://ncbi.nlm.nih.gov/pubmed/27328854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27965
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