Combining ‘Bottom-Up’ and ‘Top-Down’ Methods to Assess Ethnic Difference in Clearance: Bitopertin as an Example

BACKGROUND AND OBJECTIVES: We propose a strategy for studying ethnopharmacology by conducting sequential physiologically based pharmacokinetic (PBPK) prediction (a ‘bottom-up’ approach) and population pharmacokinetic (popPK) confirmation (a ‘top-down’ approach), or in reverse order, depending on whe...

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Veröffentlicht in:Clin Pharmacokinet
Hauptverfasser: Feng, Sheng, Shi, Jun, Parrott, Neil, Hu, Pei, Weber, Cornelia, Martin-Facklam, Meret, Saito, Tomohisa, Peck, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2015
Schlagworte:
Original Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916198/
https://ncbi.nlm.nih.gov/pubmed/26715215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0356-1
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