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Combining ‘Bottom-Up’ and ‘Top-Down’ Methods to Assess Ethnic Difference in Clearance: Bitopertin as an Example
BACKGROUND AND OBJECTIVES: We propose a strategy for studying ethnopharmacology by conducting sequential physiologically based pharmacokinetic (PBPK) prediction (a ‘bottom-up’ approach) and population pharmacokinetic (popPK) confirmation (a ‘top-down’ approach), or in reverse order, depending on whe...
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| Publicado no: | Clin Pharmacokinet |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4916198/ https://ncbi.nlm.nih.gov/pubmed/26715215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0356-1 |
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