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Physiologically Based Absorption Modelling to Predict the Impact of Drug Properties on Pharmacokinetics of Bitopertin

Bitopertin (RG1678) is a glycine reuptake inhibitor in phase 3 trials for treatment of schizophrenia. Its clinical oral pharmacokinetics is sensitive to changes in drug substance particle size and dosage form. Physiologically based pharmacokinetic (PBPK) absorption model simulations of the impact of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Parrott, Neil, Hainzl, Dominik, Scheubel, Emmanuel, Krimmer, Siegfried, Boetsch, Christophe, Guerini, Elena, Martin-Facklam, Meret
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer US 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147056/
https://ncbi.nlm.nih.gov/pubmed/24970349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9639-y
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