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H-ras inhibits the hippo pathway by promoting Mst1/Mst2 heterodimerization
The protein kinases Mst1 and Mst2 have tumor suppressor activity, but their mode of regulation is not well established. Mst1 and Mst2 are broadly expressed and may have certain overlapping functions in mammals, as deletions of both Mst1 and Mst2 together are required for tumorigenesis in mouse model...
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| Published in: | Curr Biol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4915977/ https://ncbi.nlm.nih.gov/pubmed/27238285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2016.04.027 |
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