Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

Cardiac electrophysiology models have been developed for over 50 years, and now include detailed descriptions of individual ion currents and sub-cellular calcium handling. It is commonly accepted that there are many uncertainties in these systems, with quantities such as ion channel kinetics or expr...

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Udgivet i:J Mol Cell Cardiol
Main Authors: Johnstone, Ross H., Chang, Eugene T.Y., Bardenet, Rémi, de Boer, Teun P., Gavaghan, David J., Pathmanathan, Pras, Clayton, Richard H., Mirams, Gary R.
Format: Artigo
Sprog:Inglês
Udgivet: Academic Press 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915860/
https://ncbi.nlm.nih.gov/pubmed/26611884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.11.018
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