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Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly

The cell achieves DNA double-strand break (DSB) repair in the context of chromatin structure. However, the mechanisms used to expose DSBs to the repair machinery and to restore the chromatin organization after repair remain elusive. Here we show that induction of a DSB in human cells causes local nu...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Li, Xuan, Tyler, Jessica K
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915809/
https://ncbi.nlm.nih.gov/pubmed/27269284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15129
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