PRIOR HYPOXIA PREVENTS DOWNREGULATION OF ACE-2 BY HYPEROXIA IN FETAL HUMAN LUNG FIBROBLASTS

PURPOSE/AIM OF STUDY: The renin angiotensin system is involved in experimentally induced lung fibrosis. Angiotensin (ANG)-II is profibrotic. Angiotensin converting enzyme-2 (ACE-2) cleaves ANG-II and is thus protective. ACE-2 has recently been reported to be significantly decreased under hyperoxic c...

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Detalhes bibliográficos
Publicado no:Exp Lung Res
Main Authors: Mohamed, Tarek L., Nguyen, Hang T., Abdul-Hafez, Amal, Dang, Vinh X., Dang, MyTrang T., Gewolb, Ira H., Uhal, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915782/
https://ncbi.nlm.nih.gov/pubmed/27093376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/01902148.2016.1157712
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