Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice

An increase in the ratio of cellular excitation to inhibition (E/I ratio) has been proposed to underlie the pathogenesis of neuropsychiatric disorders, such as autism spectrum disorders (ASD), obsessive-compulsive disorder (OCD), and Tourette's syndrome (TS). A proper E/I ratio is achieved via...

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Publicat a:Neuropsychopharmacology
Autors principals: Aida, Tomomi, Yoshida, Junichi, Nomura, Masatoshi, Tanimura, Asami, Iino, Yusuke, Soma, Miho, Bai, Ning, Ito, Yukiko, Cui, Wanpeng, Aizawa, Hidenori, Yanagisawa, Michiko, Nagai, Terumi, Takata, Norio, Tanaka, Kenji F, Takayanagi, Ryoichi, Kano, Masanobu, Götz, Magdalena, Hirase, Hajime, Tanaka, Kohichi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915262/
https://ncbi.nlm.nih.gov/pubmed/25662838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.26
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