Subchronic Glucocorticoid Receptor Inhibition Rescues Early Episodic Memory and Synaptic Plasticity Deficits in a Mouse Model of Alzheimer's Disease

The early phase of Alzheimer's disease (AD) is characterized by hippocampus-dependent memory deficits and impaired synaptic plasticity. Increasing evidence suggests that stress and dysregulation of the hypothalamo-pituitary-adrenal (HPA) axis, marked by the elevated circulating glucocorticoids,...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Lanté, Fabien, Chafai, Magda, Raymond, Elisabeth Fabienne, Salgueiro Pereira, Ana Rita, Mouska, Xavier, Kootar, Scherazad, Barik, Jacques, Bethus, Ingrid, Marie, Hélène
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915261/
https://ncbi.nlm.nih.gov/pubmed/25622751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.25
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