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Hypoxic repression of CYP7A1 through a HIF-1α- and SHP-independent mechanism
Liver cells experience hypoxic stress when drug-metabolizing enzymes excessively consume O(2) for hydroxylation. Hypoxic stress changes the transcription of several genes by activating a heterodimeric transcription factor called hypoxia-inducible factor-1α/β (HIF-1α/β). We found that hypoxic stress...
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| Udgivet i: | BMB Rep |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Korean Society for Biochemistry and Molecular Biology
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4915232/ https://ncbi.nlm.nih.gov/pubmed/26521940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2016.49.3.188 |
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