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Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (LSL-Kras(G12D/+);LSL-Trp53(R172H/+);Pdx-1-Cre), Its Variants and Their Application in Immuno-oncology Drug Discovery
Pancreatic ductal adenocarcinoma (PDAC) ranks fourth among cancer-related deaths in the United States and for patients with unresectable disease, treatment options are currently limited and lack curative potential. Preclinical mouse models of PDAC that recapitulate the biology of human pancreatic ca...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Curr Protoc Pharmacol |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4915217/ https://ncbi.nlm.nih.gov/pubmed/27248578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpph.2 |
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