Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (LSL-Kras(G12D/+);LSL-Trp53(R172H/+);Pdx-1-Cre), Its Variants and Their Application in Immuno-oncology Drug Discovery

Pancreatic ductal adenocarcinoma (PDAC) ranks fourth among cancer-related deaths in the United States and for patients with unresectable disease, treatment options are currently limited and lack curative potential. Preclinical mouse models of PDAC that recapitulate the biology of human pancreatic ca...

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Vydáno v:Curr Protoc Pharmacol
Hlavní autoři: Lee, Jae W., Komar, Chad A., Bengsch, Fee, Graham, Kathleen, Beatty, Gregory L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915217/
https://ncbi.nlm.nih.gov/pubmed/27248578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpph.2
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