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Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies
Telomeres maintain genomic integrity in normal cells, and their progressive shortening during successive cell divisions induces chromosomal instability. In the large majority of cancer cells, telomere length is maintained by telomerase. Thus, telomere length and telomerase activity are crucial for c...
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| Pubblicato in: | Genome Med |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4915101/ https://ncbi.nlm.nih.gov/pubmed/27323951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0324-x |
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