A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development

NFATc1 plays a critical role in double-negative thymocyte survival and differentiation. However, the signals that regulate Nfatc1 expression are incompletely characterized. Here we show a developmental stage-specific differential expression pattern of Nfatc1 driven by the distal (P1) or proximal (P2...

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Udgivet i:Nat Commun
Main Authors: Klein-Hessling, Stefan, Rudolf, Ronald, Muhammad, Khalid, Knobeloch, Klaus-Peter, Maqbool, Muhammad Ahmad, Cauchy, Pierre, Andrau, Jean-Christophe, Avots, Andris, Talora, Claudio, Ellenrieder, Volker, Screpanti, Isabella, Serfling, Edgar, Patra, Amiya Kumar
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915031/
https://ncbi.nlm.nih.gov/pubmed/27312418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11841
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