NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells

Epicutaneous application of Aldara cream containing the TLR7 agonist imiquimod (IMQ) to mice induces skin inflammation that exhibits many aspects of psoriasis, an inflammatory human skin disease. Here we show that mice depleted of B cells or bearing interleukin (IL)-10-deficient B cells show a fulmi...

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Publicat a:Nat Commun
Autors principals: Alrefai, Hani, Muhammad, Khalid, Rudolf, Ronald, Pham, Duong Anh Thuy, Klein-Hessling, Stefan, Patra, Amiya K., Avots, Andris, Bukur, Valesca, Sahin, Ugur, Tenzer, Stefan, Goebeler, Matthias, Kerstan, Andreas, Serfling, Edgar
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894959/
https://ncbi.nlm.nih.gov/pubmed/27222343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11724
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