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NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells

Epicutaneous application of Aldara cream containing the TLR7 agonist imiquimod (IMQ) to mice induces skin inflammation that exhibits many aspects of psoriasis, an inflammatory human skin disease. Here we show that mice depleted of B cells or bearing interleukin (IL)-10-deficient B cells show a fulmi...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Alrefai, Hani, Muhammad, Khalid, Rudolf, Ronald, Pham, Duong Anh Thuy, Klein-Hessling, Stefan, Patra, Amiya K., Avots, Andris, Bukur, Valesca, Sahin, Ugur, Tenzer, Stefan, Goebeler, Matthias, Kerstan, Andreas, Serfling, Edgar
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894959/
https://ncbi.nlm.nih.gov/pubmed/27222343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11724
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