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A new autoinhibited kinase conformation reveals a salt-bridge switch in kinase activation
In the structure of autoinhibited EphA2 tyrosine kinase reported herein, we have captured the entire activation segment, revealing a previously unknown role of the conserved Arg762 in kinase autoinhibition by interacting with the essential Mg(2+)-chelating Asp757. While it is well known that this Ar...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914941/ https://ncbi.nlm.nih.gov/pubmed/27324091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28437 |
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