Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells

Global demethylation is part of a conserved program of epigenetic reprogramming to naive pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to naive hypomethylated ones (serum-to-2i) is a valuable model system for epigenetic reprogramming. We present a mathematical...

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Veröffentlicht in:Mol Cell
Hauptverfasser: von Meyenn, Ferdinand, Iurlaro, Mario, Habibi, Ehsan, Liu, Ning Qing, Salehzadeh-Yazdi, Ali, Santos, Fátima, Petrini, Edoardo, Milagre, Inês, Yu, Miao, Xie, Zhenqing, Kroeze, Leonie I., Nesterova, Tatyana B., Jansen, Joop H., Xie, Hehuang, He, Chuan, Reik, Wolf, Stunnenberg, Hendrik G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914828/
https://ncbi.nlm.nih.gov/pubmed/27237052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.025
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