Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium

Cytochrome P450 (CYP) enzymes mediate mixed-function oxidation reactions important in drug metabolism. The aromatic heterocyclic cation, diphenyleneiodonium (DPI), binds flavin in cytochrome P450 reductase and inhibits CYP-mediated activity. DPI also inhibits CYP by directly interacting with heme. H...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Szilagyi, John T., Mishin, Vladimir, Heck, Diane E., Jan, Yi-Hua, Aleksunes, Lauren M., Richardson, Jason R., Heindel, Ned D., Laskin, Debra L., Laskin, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Diphenyleneiodonium Targets Heme Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914801/
https://ncbi.nlm.nih.gov/pubmed/26880746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw031
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