Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J Recombination

Variable (V), diversity (D), and joining (J) (V(D)J) recombination is the first determinant of antigen receptor diversity. Understanding how recombination is regulated requires a comprehensive, unbiased readout of V gene usage. We have developed VDJ sequencing (VDJ-seq), a DNA-based next-generation-...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Bolland, Daniel J., Koohy, Hashem, Wood, Andrew L., Matheson, Louise S., Krueger, Felix, Stubbington, Michael J.T., Baizan-Edge, Amanda, Chovanec, Peter, Stubbs, Bryony A., Tabbada, Kristina, Andrews, Simon R., Spivakov, Mikhail, Corcoran, Anne E.
Format: Artigo
Language:Inglês
Published: Cell Press 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914699/
https://ncbi.nlm.nih.gov/pubmed/27264181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.020
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