Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J Recombination

Variable (V), diversity (D), and joining (J) (V(D)J) recombination is the first determinant of antigen receptor diversity. Understanding how recombination is regulated requires a comprehensive, unbiased readout of V gene usage. We have developed VDJ sequencing (VDJ-seq), a DNA-based next-generation-...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Bolland, Daniel J., Koohy, Hashem, Wood, Andrew L., Matheson, Louise S., Krueger, Felix, Stubbington, Michael J.T., Baizan-Edge, Amanda, Chovanec, Peter, Stubbs, Bryony A., Tabbada, Kristina, Andrews, Simon R., Spivakov, Mikhail, Corcoran, Anne E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914699/
https://ncbi.nlm.nih.gov/pubmed/27264181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.020
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