Direct upregulation of STAT3 by microRNA-551b-3p deregulates growth and metastasis of ovarian cancer

3q26.2 amplification in high-grade serous ovarian cancer leads to increased expression of mature microRNA miR551b-3p, which is associated with poor clinical outcome. Importantly, miR551b-3p contributes to resistance to apoptosis and increased survival and proliferation of cancer cells in vitro and i...

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Udgivet i:Cell Rep
Main Authors: Chaluvally-Raghavan, Pradeep, Jeong, Kang Jin, Pradeep, Sunila, Silva, Andreia Machado, Yu, Shuangxing, Liu, Wenbin, Moss, Tyler, Rodriguez-Aguayo, Cristian, Zhang, Dong, Ram, Prahlad, Liu, Jinsong, Lu, Yiling, Lopez-Berestein, Gabriel, Calin, George A., Sood, Anil K., Mills, Gordon B.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914391/
https://ncbi.nlm.nih.gov/pubmed/27160903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.034
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