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Copy Number Gain of hsa-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers

Small noncoding miRNAs represent underexplored targets of genomic aberrations and emerging therapeutic targets. The 3q26.2 amplicon is among the most frequent genomic aberrations in multiple cancer lineages including ovarian and breast cancers. We demonstrate that hsa-miR-569 (hereafter designated a...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Chaluvally-Raghavan, Pradeep, Zhang, Fan, Pradeep, Sunila, Hamilton, Mark P., Zhao, Xi, Rupaimoole, Rajesha, Moss, Tyler, Lu, Yiling, Yu, Shuangxing, Pecot, Chad V., Aure, Miriam R., Peuget, Sylvain, Rodriguez-Aguayo, Cristian, Han, Hee-Dong, Zhang, Dong, Venkatanarayan, Avinashnarayan, Krohn, Marit, Kristensen, Vessela N., Gagea, Mihai, Ram, Prahlad, Liu, Wenbin, Lopez-Berestein, Gabriel, Lorenzi, Philip L., Børresen-Dale, Anne-Lise, Chin, Koei, Gray, Joe, Dusetti, Nelson J., McGuire, Sean E., Flores, Elsa R., Sood, Anil K., Mills, Gordon B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261159/
https://ncbi.nlm.nih.gov/pubmed/25490449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.10.010
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