Copy Number Gain of hsa-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers

Small noncoding miRNAs represent underexplored targets of genomic aberrations and emerging therapeutic targets. The 3q26.2 amplicon is among the most frequent genomic aberrations in multiple cancer lineages including ovarian and breast cancers. We demonstrate that hsa-miR-569 (hereafter designated a...

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Pubblicato in:Cancer Cell
Autori principali: Chaluvally-Raghavan, Pradeep, Zhang, Fan, Pradeep, Sunila, Hamilton, Mark P., Zhao, Xi, Rupaimoole, Rajesha, Moss, Tyler, Lu, Yiling, Yu, Shuangxing, Pecot, Chad V., Aure, Miriam R., Peuget, Sylvain, Rodriguez-Aguayo, Cristian, Han, Hee-Dong, Zhang, Dong, Venkatanarayan, Avinashnarayan, Krohn, Marit, Kristensen, Vessela N., Gagea, Mihai, Ram, Prahlad, Liu, Wenbin, Lopez-Berestein, Gabriel, Lorenzi, Philip L., Børresen-Dale, Anne-Lise, Chin, Koei, Gray, Joe, Dusetti, Nelson J., McGuire, Sean E., Flores, Elsa R., Sood, Anil K., Mills, Gordon B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261159/
https://ncbi.nlm.nih.gov/pubmed/25490449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.10.010
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