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Compaction and segregation of sister chromatids via active loop extrusion
The mechanism by which chromatids and chromosomes are segregated during mitosis and meiosis is a major puzzle of biology and biophysics. Using polymer simulations of chromosome dynamics, we show that a single mechanism of loop extrusion by condensins can robustly compact, segregate and disentangle c...
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| Publié dans: | eLife |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
eLife Sciences Publications, Ltd
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914367/ https://ncbi.nlm.nih.gov/pubmed/27192037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14864 |
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