PARP activation promotes nuclear AID accumulation in lymphoma cells

Activation-induced cytidine deaminase (AID) initiates immunoglobulin diversification in germinal center B cells by targeted introduction of DNA damage. As aberrant nuclear AID action contributes to the generation of B cell lymphoma, the protein's activity is tightly regulated, e.g. by nuclear/c...

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Publicado en:Oncotarget
Autores principales: Tepper, Sandra, Jeschke, Julia, Böttcher, Katrin, Schmidt, Angelika, Davari, Kathrin, Müller, Peter, Kremmer, Elisabeth, Hemmerich, Peter, Pfeil, Ines, Jungnickel, Berit
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914351/
https://ncbi.nlm.nih.gov/pubmed/26921193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7603
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