Enhancement of paclitaxel-induced breast cancer cell death via the glycogen synthase kinase-3β-mediated B-cell lymphoma 2 regulation

Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine protein kinase that is known to mediate cancer cell death. Here, we show that B-cell lymphoma 2 (Bcl-2), an anti-apoptotic protein, is regulated by GSK-3β and that GSK-3β-mediated regulation of Bcl-2 is crucial for mitochondrial-dependent ce...

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Vydáno v:BMB Rep
Hlavní autoři: Noh, Kyung Tae, Cha, Gil Sun, Kang, Tae Heung, Cho, Joon, Jung, In Duk, Kim, Kwang-Youn, Ahn, Soon-Cheol, You, Ji Chang, Park, Yeong-Min
Médium: Artigo
Jazyk:Inglês
Vydáno: Korean Society for Biochemistry and Molecular Biology 2016
Témata:
Research-Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914213/
https://ncbi.nlm.nih.gov/pubmed/26246283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2016.49.1.102
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