Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

Opioid use for pain management has dramatically increased, with little assessment of potential pathophysiological consequences for the primary pain condition. Here, a short course of morphine, starting 10 d after injury in male rats, paradoxically and remarkably doubled the duration of chronic const...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Proc Natl Acad Sci U S A
Κύριοι συγγραφείς: Grace, Peter M., Strand, Keith A., Galer, Erika L., Urban, Daniel J., Wang, Xiaohui, Baratta, Michael V., Fabisiak, Timothy J., Anderson, Nathan D., Cheng, Kejun, Greene, Lisa I., Berkelhammer, Debra, Zhang, Yingning, Ellis, Amanda L., Yin, Hang Hubert, Campeau, Serge, Rice, Kenner C., Roth, Bryan L., Maier, Steven F., Watkins, Linda R.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2016
Θέματα:
PNAS Plus
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914184/
https://ncbi.nlm.nih.gov/pubmed/27247388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602070113
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