Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

Opioid use for pain management has dramatically increased, with little assessment of potential pathophysiological consequences for the primary pain condition. Here, a short course of morphine, starting 10 d after injury in male rats, paradoxically and remarkably doubled the duration of chronic const...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Grace, Peter M., Strand, Keith A., Galer, Erika L., Urban, Daniel J., Wang, Xiaohui, Baratta, Michael V., Fabisiak, Timothy J., Anderson, Nathan D., Cheng, Kejun, Greene, Lisa I., Berkelhammer, Debra, Zhang, Yingning, Ellis, Amanda L., Yin, Hang Hubert, Campeau, Serge, Rice, Kenner C., Roth, Bryan L., Maier, Steven F., Watkins, Linda R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2016
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914184/
https://ncbi.nlm.nih.gov/pubmed/27247388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602070113
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