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Valence tautomerism in synthetic models of cytochrome P450

CytP450s have a cysteine-bound heme cofactor that, in its as-isolated resting (oxidized) form, can be conclusively described as a ferric thiolate species. Unlike the native enzyme, most synthetic thiolate-bound ferric porphyrins are unstable in air unless the axial thiolate ligand is sterically prot...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Das, Pradip Kumar, Samanta, Subhra, McQuarters, Ashley B., Lehnert, Nicolai, Dey, Abhishek
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914151/
https://ncbi.nlm.nih.gov/pubmed/27302948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600525113
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