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Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells

Disassembly of the cone-shaped HIV-1 capsid in target cells is a prerequisite for establishing a life-long infection. This step in HIV-1 entry, referred to as uncoating, is critical yet poorly understood. Here we report a novel strategy to visualize HIV-1 uncoating using a fluorescently tagged oligo...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Francis, Ashwanth C., Marin, Mariana, Shi, Jiong, Aiken, Christopher, Melikyan, Gregory B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913920/
https://ncbi.nlm.nih.gov/pubmed/27322072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005709
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