"Influence of methadone on clopidogrel in addicts on methadone maintenance therapy" Drug interaction between methadone and clopidogrel

BACKGROUND: Clopidogrel is a prodrug that converts in the liver to an active thiol metabolite, which irreversibly inhibits the platelet P2Y(12) adenosine diphosphate receptor. It seems that methadone as CYP2C19 inhibitor affects ticlopidine activity in vivo. This study aimed to test the ability of m...

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Bibliografiske detaljer
Udgivet i:Caspian J Intern Med
Main Authors: Fallah, Ferigol, Hamidikenari, Abolhasan, Sajadi, Seyed Navid, Sajadi, Seyed Rohollah, Shiran, Mohammadreza
Format: Artigo
Sprog:Inglês
Udgivet: Babol University of Medical Sciences 2016
Fag:
Short Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913717/
https://ncbi.nlm.nih.gov/pubmed/27386066
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